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Genetically diverse rats reveal a single underlying construct linking key addiction-like behaviors, challenging compulsivity as an independent measure, and offering a new perspective on vulnerability and resilience to addiction.

Preparatory states within the motor cortex play a critical role in selecting an appropriate action in response to sensory input, dependent on the context.

Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.

Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.

Participants' subjective beliefs about the treatment received in an intervention study can explain variability in mental health symptoms and cognition.

Electrophysiological recordings and optogenetic manipulations revealed the distinct roles that acetylcholine can have on the amygdala and prefrontal cortex in a Window of Opportunity Task.