Replay of recently experienced trajectories during a decision task is coupled with more effective adaptation to change, whereas replay during rest is associated with limited decision making flexibility.
Jocelyn M Richard, Nakura Stout ... Patricia H Janak
Reward-related cues elicit phasic changes in activity in ventral pallidum neurons, which predict and functionally contribute to the speed of behaviors trained on the basis of act-outcome, but not stimulus-outcome, contingencies.
Rafael Renteria, Christian Cazares ... Christina M Gremel
Chronic alcohol exposure results in a long-lasting, enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a projection-, synapse-, and behaviorally computation-specific manner.
The results of central nervous regulation in mice provide a new neural circuit and receptor regulatory mechanisms for the recovery of consciousness after midazolam administration.
Metabolomics analysis identified potential neuroactive metabolites, issued from food and microbial fermentation, that are linked to symptoms of depression, anxiety and alcohol craving.
Two distinct subpopulations of CA1 neurons that increased or decreased their firing rate during delay were identified, suggesting that they have distinct roles in the valuation process in the hippocampus.
Individual differences in generalization of aversive value (but not safety information) during human active avoidance learning specifically predict experience of anxiety and intrusive thoughts.
Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.
Shanna L Resendez, Piper C Keyes ... Brandon J Aragona
The neural mechanisms that underlie the maintenance of social bonds between prairie voles suggest that social support networks may be a powerful way of treating addiction.
