4,027 results found
    1. Neuroscience

    Ten simple rules for the computational modeling of behavioral data

    Robert C Wilson, Anne GE Collins
    Computational modeling of cognitive and neuroscience data is an insightful and powerful tool, but has many potential pitfalls that can be avoided by following simple guidelines.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nerfin-1 represses transcriptional output of Hippo signaling in cell competition

    Pengfei Guo et al.
    The zinc finger protein Nerfin-1 represses the transcriptional output of Hippo signaling in cell competition by binding to the TEA DNA-binding domain of Scalloped.
    1. Evolutionary Biology

    Sperm competition risk drives rapid ejaculate adjustments mediated by seminal fluid

    Michael J Bartlett et al.
    Seminal fluid harbours the as yet unknown mechanism that facilitates rapid adjustment of sperm velocity in response to changing sperm competition risk.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

    Joshua J Filter et al.
    Unfair competition, in which a phosphatase and a phosphoprotein inhibitor/substrate mutually sequester each other from competing substrates and enzymes, is a conserved mechanism for the control of PPP family phosphatases.
    1. Ecology
    2. Evolutionary Biology

    The evolution of distributed sensing and collective computation in animal populations

    Andrew M Hein et al.
    A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.
    1. Cell Biology
    2. Computational and Systems Biology

    Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

    Christopher Edelmaier et al.
    A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.
    1. Developmental Biology

    Roles of C/EBP class bZip proteins in the growth and cell competition of Rp (‘Minute’) mutants in Drosophila

    Jorge Blanco et al.
    Xrp1 contributes to cell competition as a heterodimer with the Drosophila C/EBP homolog Irbp18 and although rapidly evolving is itself conserved beyond Drosophila.
    1. Neuroscience

    Competition for synaptic building blocks shapes synaptic plasticity

    Jochen Triesch et al.
    Computational model reveals how the fast exchange of neurotransmitter receptors between synapses induces a competition leading to a transient form of heterosynaptic plasticity and shaping the induction of homosynaptic plasticity.
    1. Computational and Systems Biology
    2. Neuroscience

    Bottom-up and top-down computations in word- and face-selective cortex

    Kendrick N Kay, Jason D Yeatman
    A computational model reveals how response properties of category-selective regions in the visual cortex reflect both bottom-up stimulus-driven signals and top-down attentional signals from the parietal cortex.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    How competition governs whether moderate or aggressive treatment minimizes antibiotic resistance

    Caroline Colijn, Ted Cohen
    Both within and between hosts, the key factor guiding whether increasing treatment strength will increase or decrease antibiotic resistance is whether inter-strain competition is effective, not whether it is present.

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