2,894 results found
    1. Neuroscience

    Ten simple rules for the computational modeling of behavioral data

    Robert C Wilson, Anne GE Collins
    Computational modeling of cognitive and neuroscience data is an insightful and powerful tool, but has many potential pitfalls that can be avoided by following simple guidelines.
    1. Ecology
    2. Evolutionary Biology

    The evolution of distributed sensing and collective computation in animal populations

    Andrew M Hein et al.
    A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.
    1. Cancer Biology
    2. Computational and Systems Biology

    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

    Stephanie Berger et al.
    Six computationally designed and in vitro optimized protein inhibitors serve as molecular probes to reveal BCL2 profiles of different human cancers.
    1. Cell Biology
    2. Computational and Systems Biology

    Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

    Christopher Edelmaier et al.
    A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.
    1. Computational and Systems Biology
    2. Neuroscience

    Bottom-up and top-down computations in word- and face-selective cortex

    Kendrick N Kay, Jason D Yeatman
    A computational model reveals how response properties of category-selective regions in the visual cortex reflect both bottom-up stimulus-driven signals and top-down attentional signals from the parietal cortex.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Mixed outcomes for computational predictions

    Chi Van Dang
    Experimental efforts to validate the output of a computational model that predicts new uses for existing drugs highlights the inherently complex nature of cancer biology.
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    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding et al.
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak et al.
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Neuroscience

    Apical length governs computational diversity of layer 5 pyramidal neurons

    Alessandro R Galloni et al.
    Layer 5 pyramidal neurons vary substantially in dendritic excitability between primary and secondary visual cortex, likely due to a counterintuitive amplifying effect of long apical dendrites.
    1. Neuroscience

    Neural and computational processes underlying dynamic changes in self-esteem

    Geert-Jan Will et al.
    Self-esteem, the value that people ascribe to the self, is represented in the ventromedial prefrontal cortex and dynamically updated when people learn how others value them.

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