3,682 results found
    1. Neuroscience

    Neural and computational processes underlying dynamic changes in self-esteem

    Geert-Jan Will et al.
    Self-esteem, the value that people ascribe to the self, is represented in the ventromedial prefrontal cortex and dynamically updated when people learn how others value them.
    1. Neuroscience

    Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits

    Balázs B Ujfalussy et al.
    Dendrites combine the inputs that they receive from other neurons using calculations that have been optimized for those particular input patterns.
    1. Computational and Systems Biology
    2. Medicine

    Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

    Savannah F Bifulco et al.
    In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.
    1. Cancer Biology
    2. Computational and Systems Biology

    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

    Stephanie Berger et al.
    Six computationally designed and in vitro optimized protein inhibitors serve as molecular probes to reveal BCL2 profiles of different human cancers.
    1. Neuroscience

    Computational mechanisms of curiosity and goal-directed exploration

    Philipp Schwartenbeck et al.
    Distinct computational levels of uncertainty compel agents to gain information about hidden states in the world (‘active inference’) or optimise their ‘world model’ as such (‘active learning’).
    1. Neuroscience

    Neural computations underlying inverse reinforcement learning in the human brain

    Sven Collette et al.
    The human brain is capable of implementing inverse reinforcement learning, where an observer infers the hidden reward structure of a decision problem solely through observing another individual take actions.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Cell Biology
    2. Computational and Systems Biology

    Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

    Christopher Edelmaier et al.
    A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.
    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding et al.
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Neuroscience

    Constraints on neural redundancy

    Jay A Hennig et al.
    The distribution of redundant neural activity is coupled with task-relevant activity, which may limit the extent to which redundancy can be exploited by the brain for computation.

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