3,175 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves et al.
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
    1. Neuroscience

    Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions

    Vladislav Sekulić, Frances K Skinner
    The contribution of biophysical ion channels to neuron function can be predicted by taking advantage of an ongoing dialogue between model and experiment.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips et al.
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Many-molecule encapsulation by an icosahedral shell

    Jason D Perlmutter et al.
    Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg et al.
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Neuroscience

    Self-organized reactivation maintains and reinforces memories despite synaptic turnover

    Michael Jan Fauth, Mark CW van Rossum
    Despite ongoing rewiring and continuous turnover of synapses, a computational model shows that memories can maintain and even strengthen their connectivity by self-reactivating during periods without sensory input.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems biology derived source-sink mechanism of BMP gradient formation

    Joseph Zinski et al.
    Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
    1. Computational and Systems Biology
    2. Neuroscience

    Mixed-mode oscillations and population bursting in the pre-Bötzinger complex

    Bartholomew J Bacak et al.
    Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.
    1. Computational and Systems Biology
    2. Neuroscience

    Bottom-up and top-down computations in word- and face-selective cortex

    Kendrick N Kay, Jason D Yeatman
    A computational model reveals how response properties of category-selective regions in the visual cortex reflect both bottom-up stimulus-driven signals and top-down attentional signals from the parietal cortex.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.

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