1,284 results found
    1. Neuroscience

    Ten simple rules for the computational modeling of behavioral data

    Robert C Wilson, Anne GE Collins
    Computational modeling of cognitive and neuroscience data is an insightful and powerful tool, but has many potential pitfalls that can be avoided by following simple guidelines.
    1. Computational and Systems Biology
    2. Neuroscience

    Mixed-mode oscillations and population bursting in the pre-Bötzinger complex

    Bartholomew J Bacak et al.
    Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.
    1. Neuroscience

    Computational modeling of brainstem circuits controlling locomotor frequency and gait

    Jessica Ausborn et al.
    A new computational model of brainstem control of locomotor speed and gait was developed to reproduce and explain recent experimental data and propose predictions for subsequent experimental testing.
    1. Neuroscience

    Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds

    Simon M Danner et al.
    Organization of commissural and long propriospinal neuronal pathways defines gait expression in quadrupeds.
  1. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
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    1. Human Biology and Medicine
    2. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell et al.
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Physics of Living Systems

    A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies

    Raphael Zahn et al.
    A homopolymer-sphere model is shown to accurately reproduce the interactions that underpin selective gating of macromolecular transport into and out of the cell nucleus.
    1. Neuroscience

    Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age

    Lieke de Boer et al.
    Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
    1. Computational and Systems Biology
    2. Neuroscience

    Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks

    Thomas Miconi
    A biologically plausible learning rule allows recurrent neural networks to learn nontrivial tasks, using only sparse, delayed rewards, and the neural dynamics of trained networks exhibit complex dynamics observed in animal frontal cortices.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping the function of neuronal ion channels in model and experiment

    William F Podlaski et al.
    The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.

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