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    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun et al.
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Computational and Systems Biology
    2. Neuroscience

    From single neurons to behavior in the jellyfish Aurelia aurita

    Fabian Pallasdies et al.
    A multiscale computational nerve net model describes how the activity of individual neurons controls the swimming motion of a jellyfish in its hydrodynamic environment.
    1. Computational and Systems Biology
    2. Neuroscience

    Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks

    Thomas Miconi
    A biologically plausible learning rule allows recurrent neural networks to learn nontrivial tasks, using only sparse, delayed rewards, and the neural dynamics of trained networks exhibit complex dynamics observed in animal frontal cortices.
    1. Computational and Systems Biology

    Spatiotemporal establishment of dense bacterial colonies growing on hard agar

    Mya R Warren et al.
    A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping the function of neuronal ion channels in model and experiment

    William F Podlaski et al.
    The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.
    1. Neuroscience

    Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network

    Brian J Lane et al.
    Neural networks like the crustacean cardiac ganglion employ multi-faceted compensatory mechanisms to achieve the stability and robustness that are critical to long-term function.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak et al.
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Cell Biology
    2. Developmental Biology

    Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

    Emilie Guillon et al.
    A fibronectin matrix constantly remodels to the area of highest mechanical stress, and the resulting fibronectin-mediated inter-tissue adhesion impedes neural tube convergence.
    1. Developmental Biology

    Heart Morphogenesis: Twists and turns

    Emily S Noël, Jeroen Bakkers
    Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.
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    1. Computational and Systems Biology
    2. Developmental Biology

    Temporal modulation of collective cell behavior controls vascular network topology

    Esther Kur et al.
    Tissue-specific temporal regulators impinge on the VEGF/Delta-Notch pathway to vary tip cell selection pace yielding diverse densities of vascular network.