1,984 results found
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven et al.
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings et al.
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Ecology
    2. Microbiology and Infectious Disease

    Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

    Matt Lloyd Jones et al.
    Resident members of natural bacterial communities limit the growth of non-resident bacteria primarily by increasing overall community growth.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Circular RNA repertoires are associated with evolutionarily young transposable elements

    Franziska Gruhl et al.
    Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
    1. Neuroscience

    Memory recall involves a transient break in excitatory-inhibitory balance

    Renée S Koolschijn et al.
    Hippocampal activity during memory recall predicts a transient increase in the ratio between neocortical glutamate and GABA, thereby allowing otherwise dormant memories to be released.
    1. Neuroscience

    The generation of cortical novelty responses through inhibitory plasticity

    Auguste Schulz et al.
    Inhibitory synaptic plasticity provides a flexible and biologically plausible circuit mechanism to detect the novelty of bottom-up stimuli and to generate stimulus-specific adaptation.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Gut bacterial aggregates as living gels

    Brandon H Schlomann, Raghuveer Parthasarathy
    A theory of gut bacterial aggregation produces a cluster size distribution that matches that of several strains observed in zebrafish, suggesting principles generally applicable to the vertebrate gut.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Evolution of irreversible somatic differentiation

    Yuanxiao Gao et al.
    Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz et al.
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.

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