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Page 4 of 612
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak, Kara L Marshall ... Ellen A Lumpkin
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Computational and Systems Biology
    2. Neuroscience

    Interrogating theoretical models of neural computation with emergent property inference

    Sean R Bittner, Agostina Palmigiano ... John Cunningham
    Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution

    Xu Zhou, Alexander W Blocker ... Erin K O'Shea
    Computational analysis of MNase-seq data reveals that alternatively positioned nucleosomes are prevalent in both yeast and human cells and create significant heterogeneity within cell populations.
    1. Ecology
    2. Evolutionary Biology

    The evolution of distributed sensing and collective computation in animal populations

    Andrew M Hein, Sara Brin Rosenthal ... Iain D Couzin
    A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans

    Rany Abend, Diana Burk ... Bruno B Averbeck
    Applying computational modeling to quantify threat learning processes uncovers how variations in these conserved learning processes relate to anxiety severity and the neuroanatomical substrates moderating these associations.
    1. Structural Biology and Molecular Biophysics

    Computational analysis of long-range allosteric communications in CFTR

    Ayca Ersoy, Bengi Altintel ... Oded Lewinson
    A combination of computational approaches identifies a novel allosteric hotspot in cystic fibrosis transmembrane conductance regulator.
    1. Plant Biology

    Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth

    Ivan Lebovka, Bruno Hay Mele ... Thomas Greb
    Radial plant growth produces large parts of terrestrial biomass and can be computationally simulated with the help of an instructive framework of intercellular communication loops.
    1. Neuroscience

    A visual sense of number emerges from divisive normalization in a simple center-surround convolutional network

    Joonkoo Park, David E Huber
    A set of canonical computational principles implemented in a simple feedforward neural network naturally gives rise to the network's sensitivity to numerosity and its illusory effects, providing an explanation for the ubiquity of the number sense in the animal kingdom.
    1. Computational and Systems Biology

    Detection of new pioneer transcription factors as cell-type-specific nucleosome binders

    Yunhui Peng, Wei Song ... Anna R Panchenko
    A computational method has been developed for predicting the cell-type-specific binding of transcription factors to nucleosomes, and involves integration of ChIP-seq, MNase-seq, and DNase-seq data with details of nucleosome structure.
    1. Neuroscience

    The computation of directional selectivity in the Drosophila OFF motion pathway

    Eyal Gruntman, Sandro Romani, Michael B Reiser
    ON and OFF visual motion is computed with the same algorithm despite differences in circuit architecture.