1,737 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas et al.
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

    Xiaochuan Zhao et al.
    Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
    1. Neuroscience

    Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants

    Jakob Voigts et al.
    Changing which layer 6 neurons are active during sensory tasks disrupts the detection and encoding of changes, but still allows integration of sensory information in the absence of changes.
    1. Neuroscience

    Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

    Magda Dubois et al.
    Humans supplement complex, resource-demanding strategies with simple heuristics for solving the exploration-exploitation dilemma, and noradrenaline functioning controls their utilisation.
    1. Ecology

    Climate-driven deoxygenation elevates fishing vulnerability for the ocean's widest ranging shark

    Marisa Vedor et al.
    Habitats of satellite-tracked blue sharks were shifted surfaceward by an oxygen minimum zone (OMZ) at depth thereby increasing their susceptibility to capture by longline fishing focused above the OMZ.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Proofreading through spatial gradients

    Vahe Galstyan et al.
    Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.
    1. Neuroscience

    Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Sue Ann Koay et al.
    From as early as primary visual cortex and across posterior cortical areas, neural responses to visual pulses during an evidence-accumulation task exhibit a multitude of task-related amplitude modulations/gain changes.
    1. Neuroscience

    Using the past to estimate sensory uncertainty

    Ulrik Beierholm et al.
    For perceptual inference, human observers do not estimate sensory uncertainty instantaneously from the current sensory signals alone, but by combining past and current sensory inputs consistent with a Bayesian learner.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

    E Fabian Cardozo-Ojeda et al.
    Mathematical models reveal the conditions required for long-term HIV remission using autologous transplantation of hematopoietic stem cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

    Manickam Gurusaran, Owen Richard Davies
    The LINC complex has a core 6:6 structure in which KASH-binding induces head-to-head interactions between SUN trimers, suggesting force transduction between cytoskeletal and nuclear components through branched LINC complex networks.

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