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    1. Neuroscience

    Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A

    Andrew G Koesters, Mark M Rich, Kathrin L Engisch
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses

    Lucie Oriol, Melody Chao ... Thomas S Hnasko
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Senn, Leon Nissen, Yaakov Benenson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

    Mohammad E Torki, Fan Liu ... Zi Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock

    Andrea Brenna, Micaela Borsa ... Urs Albrecht
    The light-modulated protein kinase CDK5 is important for phase shifts of the circadian clock, impacting phase delays through calcium influx and signaling pathways, crucial for adapting to jet lag.
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.
    1. Neuroscience

    Accelerated signal propagation speed in human neocortical dendrites

    Gáspár Oláh, Rajmund Lákovics ... Gábor Tamás
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Jieun Park ... Michel Bagnat
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology

    Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Acute aerobic exercise does not modulate pain potentially due to differences in fitness levels and sex effects – results from a pharmacological fMRI study

    Janne I Nold, Tahmine Fadai, Christian Büchel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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