2,506 results found
    1. Chromosomes and Gene Expression
    2. Neuroscience

    FlpStop, a tool for conditional gene control in Drosophila

    Yvette E Fisher et al.
    FlpStop is a generalizable tool for conditional gene disruption and rescue and enables critical experiments examining the interactions between genes, circuits, and computation.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti et al.
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Developmental Biology
    2. Genetics and Genomics

    A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

    Fillip Port et al.
    A large-scale CRISPR library allows efficient gene disruption with spatial and temporal control in Drosophila.
    1. Neuroscience

    Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

    Patrick J O'Hern et al.
    In invertebrate and vertebrate models of Spinal Muscular Atrophy, diminished SMN protein causes Gemin3-dependent decreases in microRNA function, leading to upregulated M2 muscarinic receptor and deleterious consequences.
    1. Cell Biology
    2. Ecology
    Chlamydomonas illustration

    The Natural History of Model Organisms: From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

    Severin Sasso et al.
    Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction

    Rebeccah J Katzenberger et al.
    Use of a newly developed experimental model in fruit flies reveals that death following traumatic brain injury is largely due to a mechanism by which brain damage triggers disruption of the intestinal barrier, leading to elevated levels of glucose in the circulatory system with deleterious consequences.
    1. Cell Biology

    Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

    Vincenza Caolo et al.
    Cell protease and cell fate decisions are regulated by a bone fide force-sensor, the Piezo1 channel, and by this means achieve integration with the mechanical environment.
    1. Biochemistry and Chemical Biology

    daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

    Jonathan D Hibshman et al.
    daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.
    1. Developmental Biology
    2. Cancer Biology

    RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells

    Maaike PA van Bragt et al.
    Loss of RUNX1, a key regulator of estrogen receptor-positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh et al.
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.

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