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    1. Neuroscience

    Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain

    Gülçin Vardar, Andrea Salazar-Lázaro ... Christian Rosenmund
    A new insight into the role of syntaxin1's juxtamembrane region in controlling palmitoylation and spontaneous neurotransmitter release.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide resource for the analysis of protein localisation in Drosophila

    Mihail Sarov, Christiane Barz ... Frank Schnorrer
    A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of Drosophila development.
    1. Neuroscience

    Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

    Weiwei Liu, Anindya Ganguly ... Craig Montell
    Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

    Megan Okada, Krithika Rajaram ... Paul A Sigala
    Malaria parasites target a polyprenyl synthase enzyme to the apicoplast organelle and require its activity to produce long-chain linear isoprenoids necessary for apicoplast biogenesis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

    Yun Pyo Kang, Laura Torrente ... Gina M DeNicola
    By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
    1. Structural Biology and Molecular Biophysics

    STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

    Vivek Krishnan, Sher Ali ... Scott Earley
    STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca2+entry.
    1. Developmental Biology

    BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

    Guozhu Ning, Yu Lin ... Qiang Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

    Brennan W. McFarland, HyoJong Jang ... Catherine R. von Reyn
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

    Mengqiao Cui, Xiaoyuan Pan ... Jun-Li Cao
    RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impairment.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid