1,973 results found
    1. Developmental Biology
    2. Genetics and Genomics

    A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

    Fillip Port et al.
    A large-scale CRISPR library allows efficient gene disruption with spatial and temporal control in Drosophila.
    1. Cell Biology
    2. Computational and Systems Biology

    Functional mapping of yeast genomes by saturated transposition

    Agnès H Michel et al.
    A new method maps functional and structural features of yeast genomes with unprecedented ease and throughput, which allows identification of protein domains at the genome scale.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips et al.
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.
    1. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt et al.
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Cell Biology

    Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells

    Lorena Benedetti et al.
    eMags is an engineered photodimerizer pair for optogenetic modulation in mammalian cells that is especially suited for the manipulation of intracellular processes occurring in small volumes or subcellular organelles.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    The allosteric modulation of complement C5 by knob domain peptides

    Alex Macpherson et al.
    Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.
    1. Ecology

    Genetic transformation of the dinoflagellate chloroplast

    Isabel C Nimmo et al.
    Successful stable transformation of the dinoflagellate chloroplast genome.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.

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