2,539 results found
    1. Cell Biology
    2. Developmental Biology

    The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

    Sophie M Morgani et al.
    Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

    Caleb R Glassman et al.
    A panel of interleukin-2 partial agonists designed to exploit distinct immune cell response thresholds enabled selective activation of regulatory T cells in vivo.
    1. Microbiology and Infectious Disease

    Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection

    John A Buglino et al.
    M. tuberculosis, the bacterium that causes the disease tuberculosis, uses a signaling system that senses multiple products of the host's immune system to modify gene expression to colonize the lung.
    1. Cancer Biology

    Limited inhibition of multiple nodes in a driver network blocks metastasis

    Ali Ekrem Yesilkanal et al.
    Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
    1. Cancer Biology

    Signaling levels mold the RAS mutation tropism of urethane

    Siqi Li, Christopher M Counter
    Genetic analyses reveal that the tropism towards specific Kras driver mutations during urethane carcinogenesis appears to arise from the selection of an oncogenic mutation in normal cells that imparts a narrow window of signaling conducive for tumorigenesis.
    1. Structural Biology and Molecular Biophysics

    Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

    Subu Subramanian et al.
    Deep mutagenesis of a clamp-loader complex reveals a critical hydrogen-bonded junction that is important for allosteric communication in oligomeric AAA+ ATPases.
    1. Cell Biology

    Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

    Guangfeng Geng et al.
    Fundc1-mediated mitophagy protects renal EPO-producing cells from myofibroblastic conversion under stresses.
    1. Cell Biology

    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

    Stéphanie Torrino et al.
    UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
    1. Physics of Living Systems

    Optimal evolutionary decision-making to store immune memory

    Oskar H Schnaack, Armita Nourmohammad
    Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

    Matthew T Parker et al.
    The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.

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