2,263 results found
    1. Microbiology and Infectious Disease

    Mechanistic Microbiome Studies: A Special Issue

    Edited by Wendy S Garrett et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
  1. The silhouette of a head over a watercolour background

    Episode 62: December 2019

    In this episode we hear about bomb-proof tardigrades, how tuberculosis gets transmitted between cows and badgers, why ants do not get stuck in traffic jams, the state of mental health in academia and more.
  2. November 2016

    Episode 33: November 2016

    In this episode we hear about the first heartbeat, African sleeping sickness, elephant genetics, the rubber hand illusion and women in science.
    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak et al.
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

    Danyang Zhang et al.
    GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.
    1. Ecology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of nested Darwinian populations and the emergence of community-level heredity

    Guilhem Doulcier et al.
    Artificial selection on communities drives the evolution of interactions and establishes community-level inheritance.

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