2,263 results found
    1. Neuroscience

    Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output

    Kristina M Wright, Michael A McDannald
    Single-unit activity in the ventrolateral periaqueductal gray, a brain region implicated in organizing fear output, is found to reflect threat probability, a more versatile threat signal.
    1. Cancer Biology

    Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

    Ernesto Pérez et al.
    The oncogenic RasV12 keeps cells mutant for the tumor suppressor scribble in an undead-like condition, which is required for an amplification loop that promotes tumorigenesis.
    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau et al.
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Melanoma mystery

    Roger J Davis
    Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.
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    1. Cancer Biology
    2. Cell Biology

    Cell Proliferation: The ROCKs on which tumour cells thrive

    Simon Wilkinson, Margaret C Frame
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    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tumor Angiogenesis: Taking aim at Sox18

    Injune Kim, Gou Young Koh
    A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family.
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    1. Neuroscience

    Motor Control: A choice motif

    Sabine L Renninger, Michael B Orger
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    1. Plant Biology

    Point of View: Europe’s first and last field trial of gene-edited plants?

    Jean-Denis Faure, Johnathan A Napier
    The reclassification of gene editing as "GM" will impact on European plant sciences, making it more difficult to validate new traits in field trials and drive forward innovation.

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