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A tunable refractive index matching medium for live imaging cells, tissues and model organisms
Tobias Boothe et al.
Iodixanol supplementation provides a simple method for tuning the refractive index of live imaging media, which can greatly improve resolution and penetration depth in live imaging experiments.
Biochemistry and Chemical Biology
Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics
Kevin C Hadley et al.
STOMP is a technique that can determine the proteomic composition of any feature that is identifiable by laser scanning microscopy and is at least one cubic micron in size.
A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout
Gail McConnell et al.
A new type of microscope reveals detail of organelles inside every cell in the entirety of an intact embryo or tissue region over 100 cubic millimeters in volume.
Structural Biology and Molecular Biophysics
Imaging: Nanoscopy at low light intensities shows its potential
Travis J Gould, Joerg Bewersdorf
Microscopy: Live imaging looks deeper
Tanner C Fadero, Paul S Maddox
Iodixanol provides an easy and affordable solution to a problem that has limited resolution and brightness when imaging living samples.
Correction: A tension-adhesion feedback loop in plant epidermis
Stéphane Verger et al.
Microscopy: Looking below the surface in plants
Rui Wang, Anna A Dobritsa
A new way to culture and image flowers is uncovering the processes that take place in reproductive cells buried deep in plants.
Genetics and Genomics
Mosquitos: The taste of water
W Daniel Tracey
Female mosquitos require a specific ion-channel protein to sense the presence of fresh water in which they can lay their eggs.
Developmental Neurobiology: Shedding new light on the origins of olfactory neurons
Tanya T Whitfield
Immunology and Inflammation
Innate Like Lymphocytes: Moving at the frontline
Marco Ataíde, Wolfgang Kastenmüller
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