4,759 results found
    1. Structural Biology and Molecular Biophysics

    Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

    Ashok Sekhar et al.
    NMR-based flux measurements show that both bacterial and human Hsp70 chaperones interact with helical, as well as sheet substrates predominantly through a conformational selection mechanism.
    1. Structural Biology and Molecular Biophysics

    Molecular Chaperones: Confirmation for conformational selection

    Yajun Jiang, Charalampos G Kalodimos
    NMR studies settle part of a long-standing debate about the mechanism used by the Hsp70 chaperone to recognize substrates.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

    Marijn de Boer et al.
    Selective import via bacterial ABC importers is facilitated by a hitherto unrecognized complexity in the conformational dynamics of the substrate-binding proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synthetic single domain antibodies for the conformational trapping of membrane proteins

    Iwan Zimmermann et al.
    Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz et al.
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Biochemistry and Chemical Biology

    The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

    Mikael Holm et al.
    The antibiotic viomycin induces errors during initial codon selection by the ribosome by locking the monitoring bases in their active conformation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo

    Jyothsna Visweswaraiah, Alan G Hinnebusch
    The small subunit ribosomal protein uS7/Rps5 interacts with translation initiation factor eIF2α to stabilize first the open, and then the closed conformation of the pre-initiation complex to promote accurate start codon selection in vivo.
    1. Neuroscience

    Distinct contributions of functional and deep neural network features to representational similarity of scenes in human brain and behavior

    Iris IA Groen et al.
    Deep network features exhibit a robust correlation with brain activity in scene-selective cortex, but are not sufficient to explain human scene categorization behavior, which is strongly shaped by information about the function (possibility for action) of the scene.
    1. Structural Biology and Molecular Biophysics

    Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

    Zhu Liu et al.
    Lys63-linked diubiquitin exists as an ensemble of conformational states, each responsible for binding to a target protein through conformational selection.

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