A novel retrograde signal is involved in nerve terminal differentiation at mouse neuromuscular junctions.

Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.

The protein disulphide isomerase CRELD1 controls the biosynthesis of nicotinic acetylcholine receptors in nematode and mouse muscle.

Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.

Asparagine 88 to lysine (N88K), a prevalent congenital myasthenic syndrome mutation of Rapsyn, impairs the neuromuscular junction by disrupting agrin signaling.

Mutating a highly conserved intramembrane salt bridge unmasks structural and functional coupling between channel gating and ion permeation in the muscle nicotinic receptor.

Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.

Efficiency measures the fundamental link between agonist binding and protein conformational change, and in nicotinic receptors has 5 values that calibrate energy changes in the induced fit that triggers activation.