3,470 results found
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee et al.
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
    1. Neuroscience

    Ultra-high-field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain

    Enrico Schulz et al.
    A single-trial whole-brain analysis of three cognitive strategies to attenuate pain shows that a more effective pain attenuation is associated with increased functional connectivity across the entire brain.
    1. Developmental Biology
    2. Physics of Living Systems

    Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

    Matthew A Heinrich et al.
    Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Cancer Biology
    2. Cell Biology

    MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

    Timothy J Aikin et al.
    The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.
    1. Structural Biology and Molecular Biophysics

    Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

    Sunbin Deng et al.
    The cryo-EM structure of the human N-terminal acetyltransferase NatB bound to a cognate N-terminal alpha-synuclein peptide reveals the molecular determinants of NatB-specific protein acetylation.
    1. Neuroscience
    2. Physics of Living Systems

    Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures

    Tiberiu Tesileanu et al.
    An optimization principle allows natural-image data to predict human sensitivity to synthetic, un-natural textures with multiple gray levels.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
    1. Neuroscience

    Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

    Erin A Clark et al.
    RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Social interactions drive efficient foraging and income equality in groups of fish

    Roy Harpaz, Elad Schneidman
    Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.

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