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    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto, Akiko Yamazoe-Umemoto ... Koutarou D Kimura
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

    Jordan G McCall, Edward R Siuda ... Michael R Bruchas
    Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.
    1. Cell Biology
    2. Neuroscience

    Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

    Maryam Izadi, Eric Seemann ... Michael M Kessels
    Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Neuroscience

    Motor actions are spatially organized in motor and dorsal premotor cortex

    Nicholas G Chehade, Omar A Gharbawie
    The spatial dimension of neural activity is an organizing feature of the neural code that controls motor actions.
    1. Medicine

    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

    Cheng-Chia Tang, Christian D Castro Andrade ... Marc N Wein
    Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer, Witold J Lipski ... R Mark Richardson
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.
    1. Neuroscience

    The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

    Paolo Campus, Ignacio R Covelo ... Shelly B Flagel
    A top-down circuit generating from the prelimbic cortex and projecting to the paraventricular nucleus of the thalamus mediates individual differences in cue-elicited responding by affecting subcortical dopamine-dependent incentive learning.
    1. Evolutionary Biology
    2. Neuroscience

    Neural mechanisms of modulations of empathy and altruism by beliefs of others’ pain

    Taoyu Wu, Shihui Han
    Beliefs of others’ pain provide a cognitive basis of human empathy and altruism by modulating empathic brain activity.