143 results found
    1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel et al.
    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.
    1. Computational and Systems Biology

    The structural connectome constrains fast brain dynamics

    Pierpaolo Sorrentino et al.
    The fast spreading of neural activity across the brain has a complex structure, imposed by the white-matter bundles.
    1. Evolutionary Biology
    2. Neuroscience

    Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques

    Luqi Cheng et al.
    Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld et al.
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Neuroscience

    Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

    Jonas Hansen Kymre et al.
    Electrophysiological and morphological identification of individual pheromone projection neurons in male moth reveals a coding system for optimizing mate search strategy, including computation of three female-produced signals in distinct protocerebral regions.
    1. Developmental Biology
    2. Neuroscience

    A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

    Brandon Mark et al.
    Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.
    1. Neuroscience

    Corollary discharge promotes a sustained motor state in a neural circuit for navigation

    Ni Ji et al.
    A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
    1. Genetics and Genomics
    2. Neuroscience

    Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

    Quadri Adewale et al.
    Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
    1. Neuroscience

    Permeabilization-free en bloc immunohistochemistry for correlative microscopy

    Kara A Fulton, Kevin L Briggman
    Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.
    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park et al.
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.

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