145 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

    Amit Kumar, Oscar Vadas ... Stephen Matthews
    The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    In situ cryo-ET structure of phycobilisome–photosystem II supercomplex from red alga

    Meijing Li, Jianfei Ma ... Sen-Fang Sui
    The nature of the phycobilisome–photosystem II supercomplex on the native thylakoid determined with cryo-electron tomography at an unprecedented resolution reveals that one phycobilisome interconnects with six photosystem monomers.
    1. Computational and Systems Biology
    2. Developmental Biology

    Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

    Tarun Kumar, Leo Blondel, Cassandra G Extavour
    Regulatory networks of genes controlling different aspects of insect reproduction have been identified by a systems-level analysis of quantitative phenotypic information obtained from the loss of individual cell signaling genes.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen, Ines Winkler ... Titia K Sixma
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.
    1. Cell Biology

    The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

    Faye M Nixon, Cristina Gutiérrez-Caballero ... Stephen J Royle
    Microtubules of mitotic spindle fibers are positioned and held together by a meshwork of multipolar connectors.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

    Helen R McPherson, Cedric Duval ... Robert AS Ariëns
    Fibrinogen, a key protein involved in blood coagulation, contains a disordered and previously poorly characterised region called αC that plays a critical role in fibrin fibre growth and clot stability.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Robust model-based analysis of single-particle tracking experiments with Spot-On

    Anders S Hansen, Maxime Woringer ... Xavier Darzacq
    Spot-On is an easy-to-use website that makes a rigorous and bias-corrected modeling framework for analysis of single-molecule tracking experiments available to all.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Three F-actin assembly centers regulate organelle inheritance, cell-cell communication and motility in Toxoplasma gondii

    Nicolò Tosetti, Nicolas Dos Santos Pacheco ... Damien Jacot
    Toxoplasma gondii formins have several non-overlapping roles including generating an apico-basal flux of F-actin that is controlled by phosphorylation and methylation and is essential for motility.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Determinants shaping the nanoscale architecture of the mouse rod outer segment

    Matthias Pöge, Julia Mahamid ... Wolfgang Baumeister
    Cryo-electron tomography of close-to-native rod outer segments resolves connectors between disks and a scaffold at the disk rim enforcing the high membrane curvature of the unique long-range organization in these rhodopsin-rich light-sensitive subcellular organelles.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

    Simon Imhof, Jiayan Zhang ... Kent L Hill
    Cryo electron tomography provides the first high-resolution 3D axoneme structure from any pathogenic organism, revealing novel structures that support the unique motility of these pathogens through host tissues.

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