54 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish

    Uwe Irion et al.
    Melanophores and xanthophores interact via heteromeric gap junctions composed of Connexin 41.8 and Connexin 39.4 to establish the adult pigment pattern in zebrafish.
    1. Structural Biology and Molecular Biophysics

    CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits

    Louise Meigh et al.
    A CO2 receptor and a mechanism for the CO2-mediated opening of gap junction hemichannels have been identified.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

    Louise Meigh et al.
    Building on previous work (Meigh et al., 2013) we show that A88V, a mutation in connexin26 (Cx26) that causes Keratitis-Ichthyosis-Deafness (KID) syndrome in humans, is linked to a lack of sensitivity to CO2 by Cx26 hemichannels.
    1. Neuroscience

    A genetic basis for molecular asymmetry at vertebrate electrical synapses

    Adam C Miller et al.
    Electrical synapses are neuronal, gap-junction-based connections found throughout the nervous system that, in the escape circuit of zebrafish, are composed of molecularly distinct pre- and postsynaptic junction forming proteins that are required for behavioral performance.
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
    1. Neuroscience

    Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse

    Melanie Falgairolle et al.
    Motoneuron activity provides feedback to the spinal network responsible for generating locomotion in the developing mouse spinal cord.
    1. Developmental Biology

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Yun Huang et al.
    Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.
    1. Neuroscience

    A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

    Kylie S Chew et al.
    A single subpopulation of photoreceptors constitutes a shared node in the neural networks that regulate light-dependent maturation of the circadian clock and light-independent refinement of retinal ganglion cell projections to the brain.
    1. Cell Biology
    2. Developmental Biology

    Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

    Kasmir Ramo et al.
    The kinase JNK is required in endothelial cells for the development of native collateral arteries.

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