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    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
  1. Living Science: Grandmother elephants

    Eve Marder
    As new technology makes it possible to perform experiments that were unimaginable a decade ago, Eve Marder argues that we can still learn from the past.
  2. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
  3. Point of View: The sustainable professor

    Elizabeth S Haswell
    Responsible agricultural practices provide a useful lens through which to consider the lives and careers of researchers.
    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Neuroscience

    A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval

    Melissa Hebscher et al.
    Inhibitory noninvasive stimulation to the precuneus disrupts theta and gamma oscillatory coupling between medial temporal lobes and neocortical regions during complex personal memory retrieval.
    1. Neuroscience

    Brain signatures of a multiscale process of sequence learning in humans

    Maxime Maheu et al.
    Evidence for multiple brain systems for sequence processing involving statistical inferences at multiple scales.
    1. Neuroscience

    Emotional faces guide the eyes in the absence of awareness

    Petra Vetter et al.
    When emotional faces are rendered invisible, our eyes look towards fearful faces and away from angry faces.
    1. Neuroscience

    The recovery of standing and locomotion after spinal cord injury does not require task-specific training

    Jonathan Harnie et al.
    Restoring locomotion after complete spinal cord injury does not require locomotor training, only the return of sufficient excitability within neurons of the spinal cord.
    1. Human Biology and Medicine
    2. Neuroscience

    Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors

    Joshua S Talboom et al.
    An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.