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Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.

Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.

An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.

Combined experimental and theoretical analysis identifies a molecular mechanism akin to working memory that enables single cells to perform complex navigation tasks in changing growth factor fields, beyond simple stimulus-response associations.

Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.

RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

The ability of transposable elements to epigenetically influence adjacent genes impacts genome evolution by driving substantial variation in transposon numbers between species.

An international collaboration between five independent research groups replicates findings confirming the importance of aquaporin-4 in glymphatic solute transport using five different mouse knockout lines.

Metabolic supplementation attenuates age-dependent declines in regeneration.

Molecular, cellular and behavioral genetic approaches in Platynereis dumerilii indicate that r-Opsins can act as ancient, light-dependent modulators of mechanosensation, and suggest that light-independent mechanosensory roles of r-Opsins evolved secondarily.