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    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Flavodiiron proteins 1–to-4 function in versatile combinations in O2 photoreduction in cyanobacteria

    Anita Santana-Sanchez, Daniel Solymosi ... Yagut Allahverdiyeva
    In vivo evidence is provided indicating that Flv2/Flv4, together with Flv1/Flv3, mediate O2 photoreduction downstream of PSI in a highly coordinated manner.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Cell Biology

    Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

    Gian-Luca McLelland, Thomas Goiran ... Edward A Fon
    A crucial step during the mitophagy cascade involves the disassembly of connections between mitochondria and the endoplasmic reticulum via the retrotranslocation of Mfn2 tethering complexes by the Parkinson's disease genes PARKIN and PINK1, as well as the ATPase VCP/p97.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Formicine ants swallow their highly acidic poison for gut microbial selection and control

    Simon Tragust, Claudia Herrmann ... Heike Feldhaar
    Poison acidified crops sanitize food and limit disease transmission while at the same time structuring the gut microbiota and thus contribute to the ecological and evolutionary success of formicine ants.
    1. Cell Biology

    A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia

    Tooba Quidwai, Jiaolong Wang ... Pleasantine Mill
    Electron tomography and biochemical approaches demonstrate a direct role for WDR35, beyond integrity of the IFT-A holocomplex, in the formation and fusion of electron-dense-coated vesicles to the ciliary sheath and pocket for delivery of cargos necessary for axoneme elongation.
    1. Developmental Biology
    2. Evolutionary Biology

    Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

    James W Truman, Jacquelyn Price ... Tzumin Lee
    The mushroom body neuropils of the larval brain have regions that share neurons and functions with the adult and larval-specific regions built with 'doomed' neurons or cells that trans-differentiate for temporary larval function before assuming their adult phenotypes at metamorphosis.
    1. Cell Biology

    LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans

    Romane Leboutet, Céline Largeau ... Renaud Legouis
    A genetic approach in Caenorhabditis elegans shows that the cleaved and cytosolic form of the ubiquitin-like protein LGG-1/GABARAP is sufficient for both autophagy and embryonic development.
    1. Stem Cells and Regenerative Medicine

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló, Chun-Chun Chen ... Erich D Jarvis
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari, Tomotsune Ameku ... Ryusuke Niwa
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.