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BRAF inhibitors achieve monomer or dimer selectivity through their ability to modulate dimerization and allosteric communication.

Molecular dynamics simulation assisted engineering of recombinant soluble human ACE2 N-glycosylation by site-directed mutagenesis or glycosidase treatment yields a superior SARS-CoV-2 decoy receptor.

The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.

The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.

In budding yeast, nascent polarity sites engage in a winner-takes-all contest to determine a single front.

Escherichia coli exhibits sensitive chemotaxis to potassium, mediated by differential responses of Tar and Tsr chemoreceptors to intracellular pH changes induced by potassium concentration gradients.

Sodium ions but not protons induce defined helix movements in a sodium/proton antiporter and suggest a mechanism for Na + binding and transport.

A CO₂ receptor and a mechanism for the CO₂-mediated opening of gap junction hemichannels have been identified.

The sour receptor, OTOP1, and related proton channel OTOP3 are steeply activated by extracellular protons while OTOP2 is active over a broad pH range and differences in gating are partly attributed to extracellular domains.

Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.