18,192 results found
    1. Ecology
    2. Immunology and Inflammation

    Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

    Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
    Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.
    1. Cancer Biology

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

    Caroline Contat, Pierre-Benoit Ancey ... Etienne Meylan
    In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy

    Sharon R Cooper, James D Jontes, Marcos Sotomayor
    Structural and binding studies provide insight into the molecular mechanism of protocadherin-19-mediated adhesion and into the biochemical basis of neurodevelopmental disease.
    1. Epidemiology and Global Health

    Social contact patterns and implications for infectious disease transmission – a systematic review and meta-analysis of contact surveys

    Andria Mousa, Peter Winskill ... Charles Whittaker
    Differences in patterns of social contact between settings have consequences for the spread and transmission of respiratory pathogens and the effectiveness of different measures aimed at their control.
    1. Neuroscience

    Value signals guide abstraction during learning

    Aurelio Cortese, Asuka Yamamoto ... Benedetto De Martino
    Valuation of sensory information in the ventromedial prefrontal cortex plays a key function in constructing the abstract representations that guide complex behaviours.
    1. Biochemistry and Chemical Biology

    Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

    Hudson W Coates, Isabelle M Capell-Hattam ... Andrew J Brown
    Hypoxic accumulation of squalene, the substrate of squalene monooxygenase, triggers its proteasomal truncation to a constitutively active variant that preserves downstream sterol synthesis.
    1. Immunology and Inflammation
    2. Medicine

    3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography

    Marina Eckermann, Jasper Frohn ... Tim Salditt
    Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Local genetic context shapes the function of a gene regulatory network

    Anna Nagy-Staron, Kathrin Tomasek ... Calin C Guet
    The phenotype of a gene regulatory network depends both qualitatively and quantitatively on the local genetic context of its individual components and cannot necessarily be predicted solely from network's topology.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes

    Daniel B Cortes, Karen L McNally ... Francis J McNally
    Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

    Joel M Swenson, Serafin U Colmenares ... Gary H Karpen
    Identification of novel components and regulators of heterochromatin reveals a spatially complex and dynamic organization.

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