4,884 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure

    Sarah Jacquelyn Smith et al.
    A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
    1. Microbiology and Infectious Disease

    ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis

    Thurston Herricks et al.
    Time-lapse live cell imaging of single Mycobacterium tuberculosis bacilli growing into small colonies enables their rapid phenotypic characterization including anti-microbial resistance and heteroresistance in clinical isolates.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Cell Biology
    2. Developmental Biology

    Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

    Nuno Costa-Borges et al.
    Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.
    1. Structural Biology and Molecular Biophysics

    ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

    Horia Vais et al.
    Calcium release from the endoplasmic reticulum through the IP3 receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Neuroscience

    Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

    Alexandra N Trelle et al.
    The strength of pattern completion during memory retrieval, indexed by hippocampal activity and cortical reinstatement, explains within- and across-individual variability in episodic memory in older adults.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Universally high transcript error rates in bacteria

    Weiyi Li, Michael Lynch
    Fundamental details of the rate and molecular spectrum of transcript errors were revealed in four bacterial species, providing novel insights into transcriptional fidelity and RNA quality-control in prokaryotes.
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld et al.
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
  1. COVID-19: A collection of articles

    Edited by Jos WM van der Meer et al.
    eLife has published the following articles on SARS-CoV-2 and COVID-19.

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