The person-specific adjusted HbA_1c addresses non-glycaemic variation in laboratory HbA_1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.

Cleavage of pannexin-1 channel by caspases facilitates the loss of intracellular ATP level and attenuates glycolytic metabolism of apoptotic cells.

Despite evidence of significant anti-cryptococcal activity in vitro and animal models, including synergy with other antifungal agents, high-dose tamoxifen has no impact on cerebrospinal fluid sterilization in cryptococcal meningitis.

Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.

Genetic, behavioral, and biochemical evidence reveals that the Drosophila TRPγ channel is required in neuroendocrine cells for the starvation-induced switch in preference to less palatable but more nutritive food.

Mice carrying a near-complete human chromosome 21 are hypermetabolic and have increased thermogenesis due to sarcolipin overexpression in the skeletal muscle, leading to persistent uncoupling of the sarco(endo)plasmic reticulum Ca²⁺ ATPase pump activity and heat generation.

A switch-like cell fate divergence revealed by continuous single-cell tracking during entry into quiescence.

Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.

Alpha EEG oscillations emerge at 4 months of age during sevoflurane general anesthesia, and unlike in adults, have a widespread spatial distribution that likely reflects differences in brain development.

Enteroendocrine cells sense nutrients in the gut and regulate digestive physiology but are rendered insensitive following fat ingestion due to alteration of gut microbiota.