156 results found
    1. Cell Biology

    The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

    Catherine A Makarewich et al.
    Cardiac-specific overexpression of a recently discovered micropeptide, DWORF, enhances calcium cycling and contractility in the heart and rescues the heart failure phenotype of a genetic mouse model of dilated cardiomyopathy.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Developmental Biology
    2. Neuroscience

    Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

    Alexandre B Roland et al.
    Cannabinoids inhibit neuronal expansion and growth through the rapid contraction of actomyosin.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

    Maria Paz Prada et al.
    A multi-pronged approach shows that a Gs-coupled purinergic receptor is a sensor for glucose-mediated, PKA-dependent potentiation of vascular L-type calcium channels and vasoconstriction.
    1. Developmental Biology

    Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling

    Kerim B Kaylan et al.
    Mechanical stress plays a cooperative role with Notch in biliary differentiation of liver progenitors, supporting a model of liver development in which biomechanical cues are key inducers of cell fate.
    1. Cancer Biology
    2. Cell Biology

    Cell Proliferation: The ROCKs on which tumour cells thrive

    Simon Wilkinson, Margaret C Frame
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    1. Developmental Biology

    Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

    Hervé Alégot et al.
    A morphogen gradient can trigger tissue elongation via a control of apical cell pulsing and without a planar cell polarity requirement.
    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.
    1. Cell Biology

    A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

    Philippe Bun et al.
    On entry to meiosis, chromosomes scattered in the large oocyte nucleus of starfish are collected by an F-actin network, which contracts by an unexpected, myosin-independent mechanism based on local assembly and global disassembly of actin filaments.
    1. Cell Biology
    2. Developmental Biology

    Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

    Torey R Arnold et al.
    In epithelial cells, anillin organizes the medial-apical actomyosin cortex into a contractile load-bearing structure and increases tissue-level stiffness.

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