138 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

    Agata Wesolowska-Andersen et al.
    Combination of deep learning models trained on tissue-specific genomic data and fine-mapping approaches supports efforts to identify causal variants and mechanisms at GWAS loci.
    1. Neuroscience

    How biological attention mechanisms improve task performance in a large-scale visual system model

    Grace W Lindsay, Kenneth D Miller
    Implementing neural changes associated with attention in a deep neural network causes performance changes that mimic those observed in humans and macaques.
    1. Neuroscience

    What the success of brain imaging implies about the neural code

    Olivia Guest, Bradley C Love
    For brain imaging to be useful despite its limitations in measuring neural activity, the neural code must be smooth both in a traditional sense and functionally.
    1. Neuroscience

    'Artiphysiology' reveals V4-like shape tuning in a deep network trained for image classification

    Dean A Pospisil et al.
    Single units in a deep convolutional neural network trained for image classification develop shape selectivity that is similar to that found in the primate visual cortex.
    1. Computational and Systems Biology
    2. Neuroscience

    A model for focal seizure onset, propagation, evolution, and progression

    Jyun-you Liou et al.
    Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.
    1. Neuroscience

    Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy

    Wu Chen et al.
    Two genetically distinct Stxbp1 haploinsufficiency mouse models exhibit seizures and impairments in cognitive, psychiatric, and motor functions, representing robust preclinical models of STXBP1 encephalopathy with both construct and face validity.
    1. Neuroscience

    Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

    Laura D Knogler et al.
    Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.
    1. Structural Biology and Molecular Biophysics

    Protein denaturation at the air-water interface and how to prevent it

    Edoardo D'Imprima et al.
    Hydrophilized graphene prevents protein denaturation at the air-water interface.
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Neuroscience

    Phase-tuned neuronal firing encodes human contextual representations for navigational goals

    Andrew J Watrous et al.
    Prospective navigational goals are represented by single neuron firing rates and firing relative to slow oscillatory phase (phase coding) in the human medial temporal lobe.

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