384 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    The cyanobacterial circadian clock follows midday in vivo and in vitro

    Eugene Leypunskiy, Jenny Lin ... Michael J Rust
    The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock limit cycle.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
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    1. Neuroscience

    A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

    Ana S Machado, Dana M Darmohray ... Megan R Carey
    Analysis of 3D paw kinematics and whole-body coordination in freely walking mice isolates specific features of gait ataxia and supports the hypothesis that the cerebellum provides an internal forward model for motor control.
    1. Biochemistry and Chemical Biology

    LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

    Sandy Mattijssen, Aneeshkumar G Arimbasseri ... Richard J Maraia
    The messenger RNA encoding La-related protein-4 (LARP4) contains a short region of instability whose codon clusters are sensitive to low abundance tRNAs that when elevated increase LARP4 activity for poly(A) lengthening of ribosomal protein mRNAs and other mRNAs.
    1. Cell Biology

    Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing

    Annina Denoth-Lippuner, Marek Konrad Krzyzanowski ... Yves Barral
    The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.
    1. Neuroscience

    Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

    Sarah E Canetta, Emma S Holt ... Christoph Kellendonk
    Prefrontal PV interneuron activity during development is necessary for prefrontal circuit maturation, supporting adult prefrontal network function and cognitive flexibility.
    1. Biochemistry and Chemical Biology

    POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan

    Ameya S Walimbe, Hidehiko Okuma ... Kevin P Campbell
    Protein O-Mannose Kinase enables Like-acetyl-glucosaminyltransferase 1 to elongate matriglycan on α-dystroglycan, thereby allowing matriglycan to function as a scaffold for extracellular matrix proteins and prevent muscular dystrophy.
    1. Developmental Biology
    2. Neuroscience

    Automated deep-phenotyping of the vertebrate brain

    Amin Allalou, Yuelong Wu ... Mehmet Fatih Yanik
    Automated whole-brain analysis of gene expression at cellular resolution detects previously overlooked phenotypes in mutants and reveals parallels between the forebrains of zebrafish and mammals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

    Sonja Kroschwald, Shovamayee Maharana ... Simon Alberti
    A comparison in yeast and human cells reveals a remarkable variability in the properties of RNP granules and highlights a key role for protein disaggregation machines in regulating RNP granule assembly.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

    Bradley M Colquitt, Kelly Li ... Michael S Brainard
    Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.

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