384 results found
    1. Structural Biology and Molecular Biophysics

    Conservation of the cooling agent binding pocket within the TRPM subfamily

    Kate Huffer, Matthew CS Denley ... Kenton J Swartz
    The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.
    1. Genetics and Genomics

    Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression

    Ambuj Upadhyay, Nathan R Feltman ... Michael Smanski
    Two distinct genetic biocontrol methods work synergistically to yield a novel approach in the fight against pest organisms.
    1. Neuroscience

    The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

    Lina Ni, Mason Klein ... Paul A Garrity
    Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool sensation in fruit fly larvae.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Conformist social learning leads to self-organised prevention against adverse bias in risky decision making

    Wataru Toyokawa, Wolfgang Gaissmaier
    Mathematical modelling and large-scale online experiments revealed that learning from others can induce 'smarter' decisions even when most individuals are biased towards adverse risk aversion.
    1. Neuroscience

    The control of tonic pain by active relief learning

    Suyi Zhang, Hiroaki Mano ... Ben Seymour
    The brain has a central cortico-striatal learning circuit that suppresses ongoing pain after injury when actively learning about things that could remove the cause of the pain.
    1. Developmental Biology

    The Drosophila Individual Activity Monitoring and Detection System (DIAMonDS)

    Ki-Hyeon Seong, Taishi Matsumura ... Siu Kang
    The DIAMonDS can automatically and sequentially identify time points of multiple life cycle events such as pupariation, eclosion, and death in individual flies at high temporal resolution and large scale.
    1. Computational and Systems Biology

    Neural arbitration between social and individual learning systems

    Andreea Oliviana Diaconescu, Madeline Stecy ... Philippe N Tobler
    Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.
    1. Biochemistry and Chemical Biology

    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

    Gregory M Solis, Rozina Kardakaris ... Michael Petrascheck
    Directly targeting the ribosome to attenuate translation partly mimics the integrated stress response, increasing lifespan and preserving protein folding capacity even in older individuals with dysfunctional stress response signaling.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Host-associated microbe PCR (hamPCR) enables convenient measurement of both microbial load and community composition

    Derek S Lundberg, Pratchaya Pramoj Na Ayutthaya ... Detlef Weigel
    hamPCR is a cost-effective and transformative amplicon sequencing strategy to describe microbiota composition and measure its overall abundance, applicable to all samples in which host and microbial DNA are co-extracted.

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