41 results found
    1. Genetics and Genomics
    2. Neuroscience

    Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

    Kazuhiro Shimomura, Vivek Kumar ... Joseph S Takahashi
    A gene that codes for a transcription factor that is involved in lipid and carbohydrate metabolism also has a role in the regulation of circadian rhythms.
    1. Ecology

    Climate-mediated cooperation promotes niche expansion in burying beetles

    Syuan-Jyun Sun, Dustin R Rubenstein ... Sheng-Feng Shen
    Cooperation enables burying beetles to outcompete flies and adapt to a wider range of temperatures as thermal generalists.
    1. Neuroscience

    Intercollicular commissural connections refine the representation of sound frequency and level in the auditory midbrain

    Llwyd David Orton, Adrian Rees
    Deactivation of one side of the auditory midbrain while recording in the other shows that the two sides cooperate in processing frequency and in enhancing the encoding of sound level.
    1. Ecology

    Parental effects alter the adaptive value of an adult behavioural trait

    Rebecca M Kilner, Giuseppe Boncoraglio ... Hanna Kokko
    The adaptive value of social behaviour exhibited in adult life varies with conditions experienced in early life, and poorer conditions may promote conflict over cooperation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

    Madlen Matz-Soja, Christiane Rennert ... Rolf Gebhardt
    The Hedgehog signalling pathway is a master regulator of lipid metabolic processes and their zonation in the adult liver of mice and humans.
    1. Neuroscience

    Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network

    Marc Chevalier, Natalia Toporikova ... Muriel Thoby-Brisson
    Pacemaker neurons are present in the preBötC circuitry of mouse embryos and their role in driving respiratory network activity changes during the critical period immediately before birth.
    1. Neuroscience

    Vocal development in a Waddington landscape

    Yayoi Teramoto, Daniel Y Takahashi ... Asif A Ghazanfar
    An integrated landscape framework shows how the coordinated changes in vocal apparatus, muscles, nervous system, and social interaction together influence the trajectory of vocal development.
    1. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt, Qinyu Zhang ... Konstantinos Anastassiadis
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Cancer Biology

    Arid1a restrains Kras-dependent changes in acinar cell identity

    Geulah Livshits, Direna Alonso-Curbelo ... Scott W Lowe
    Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng, Mary A Yui ... Hao Yuan Kueh
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.

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