441 results found
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells et al.
    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.
    1. Cell Biology
    2. Immunology and Inflammation

    Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

    Lindsey Araujo et al.
    Metabolic switches between oxidative phosphorylation and aerobic glycolysis plus glutaminolysis direct T cell function by altering the flux of glucose and glutamine to N-glycosylation.
    1. Structural Biology and Molecular Biophysics

    Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules

    Daifei Liu et al.
    A novel algorithm is used to solve the first 3D reconstruction of a stepping kinesin dimer on microtubules, directly visualizing the conformational effects of inter-head strain and giving novel insights into the motility mechanism.
    1. Neuroscience

    A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

    Zhuo Guan et al.
    A suppressor screen of dominant-negative synaptotagmin-induced lethality in Drosophila identifies key properties of the protein that regulate fusion, including the SNARE interaction surface.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

    Jeehae Park et al.
    The sharp expression pattern driven by a classic, simple animal enhancer is determined by multiple molecular mechanisms, not only cooperative binding of the activating transcription factor as was previously thought.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Coevolution-based inference of amino acid interactions underlying protein function

    Victor H Salinas, Rama Ranganathan
    A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
    1. Chromosomes and Gene Expression

    Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

    Oliver Willhoft et al.
    Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric modulation in monomers and oligomers of a G protein-coupled receptor

    Rabindra V Shivnaraine et al.
    Allosteric modulation in the M2 muscarinic receptor derives from a mix of interactions within and between the protomers of an oligomer.
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell et al.
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
    1. Physics of Living Systems

    Measuring cis-regulatory energetics in living cells using allelic manifolds

    Talitha L Forcier et al.
    A novel strategy is presented for quantitatively measuring protein-DNA and protein-protein interactions that regulate transcription in living cells.

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