68 results found
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Cell Biology

    Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation

    Saralin Davis et al.
    Phosphorylation of a core trafficking component, the COPII coat subunit Sec24, regulates cross-talk between the secretory and autophagy machinery during starvation.
    1. Cell Biology
    2. Evolutionary Biology

    Characterization of TSET, an ancient and widespread membrane trafficking complex

    Jennifer Hirst et al.
    A missing link between the AP complexes and COPI sheds light on the evolution of vesicle coat proteins and trafficking pathways in the earliest eukaryotes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

    Florian Wilfling et al.
    The targeting of proteins from the endoplasmic reticulum to lipid droplets relies on surface modulation of the lipid droplet by the Arf1/COPI machinery.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The structure of the COPI coat determined within the cell

    Yury S Bykov et al.
    Cryo-electron tomography of COPI vesicles in the Golgi reveals coat structure, disassembly dynamics, cargo binding, and morphological variability.
    1. Plant Biology

    The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant-specific motif

    Upendo Lupanga et al.
    Analysis of the Arabidopsis V-ATPase reveals convergent evolution of differential targeting as well as redundancy of the endosomal and vacuolar isoforms during vegetative development.
    1. Cell Biology

    ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration

    Joanne Chia et al.
    The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.
    1. Cell Biology

    The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack

    Hieng Chiong Tie et al.
    Transport machinery localizes at the cisternal rim while modification machinery localizes at the interior.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

    Wenfu Ma et al.
    The COPII coat protein, in association with p24 machinery molecules, actively excludes misfolded and resident proteins from endoplasmic reticulum-derived transport vesicles.

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