677 results found
    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer et al.
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Cancer Biology
    2. Human Biology and Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus et al.
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Cancer Biology

    Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

    Joan C Smith, Jason M Sheltzer
    Gene copy number provides more prognostic information than gene mutation status in cancer.
    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg
    Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.
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    1. Cancer Biology
    2. Cell Biology

    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

    Debjani Pal et al.
    Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.
    1. Cancer Biology
    2. Human Biology and Medicine

    Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

    Brenton R Paolella et al.
    Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.
    1. Cancer Biology
    2. Human Biology and Medicine

    Cancer Therapeutics: Partial loss of genes might open therapeutic window

    Bo Liu, Omar Abdel-Wahab
    The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.
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    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
    1. Cancer Biology

    Reproducibility in Cancer Biology: Melanoma mystery

    Roger J Davis
    Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.
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    1. Human Biology and Medicine

    Point of View: How should the applications of genome editing be assessed and regulated?

    Robin Fears, Volker ter Meulen
    An EASAC working group on genome editing recommends that regulators should focus on specific applications of these new techniques rather than attempting to regulate genome editing itself as a new technology.

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