2,089 results found
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo et al.
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.
    1. Neuroscience

    Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

    Alex J Smith et al.
    Solute movement in brain extracellular space is determined by solute diffusion, and does not depend on convection or aquaporin-4 expression as predicted by the glymphatic mechanism.
    1. Biochemistry and Chemical Biology

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Neuroscience

    Chronic pain induces generalized enhancement of aversion

    Qiaosheng Zhang et al.
    Chronic pain distorts intensity coding in the anterior cingulate cortex to give rise to generalized anatomically nonspecific enhancement in pain aversion.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

    Mitsuhiro Endoh et al.
    PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

    Simon Weinberger et al.
    The coding sequences of a very highly conserved family of neurogenic transcription factors from different species have evolved to generate proteins that have different life times causing them to display quantitatively different neural induction potentials.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al.
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al.
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Biochemistry and Chemical Biology

    Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

    Johannes Rudolph et al.
    By moving between DNA segments like a child swinging on monkey bars, poly(ADP-ribose) polymerase 1 explores possible DNA damage sites more effectively.

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