249 results found
  1. In technology: A summary of the Libero Community Sprint

    Paul Shannon, eLife Head of Technology, reports on the outcomes from the Libero Community Sprint held in August 2018.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

    Doreen Matthies et al.
    The structure of a voltage-activated potassium channel in lipid nanodiscs solved using cryo-electron microscopy is similar to previous X-ray structures, and provides insights into the mechanism of C-type inactivation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Efficient support of virus-like particle assembly by the HIV-1 packaging signal

    Mauricio Comas-Garcia et al.
    The packaging signal in HIV-1 genomic RNA supports in vitro particle assembly more efficiently than control RNAs, probably explaining its selective packaging during virus assembly in vivo.
    1. Structural Biology and Molecular Biophysics

    Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

    Jingpeng Ge et al.
    Structures of a mouse PCDH15 and LHFPL5 complex, two proteins involved in converting sound into electrical signals, illuminate how mechanical stimuli are delivered to the membrane of inner ear hair cells.
    1. Neuroscience

    Stimulus vignetting and orientation selectivity in human visual cortex

    Zvi N Roth et al.
    Functional MRI measurements of orientation reflect coarse-scale biases that are wholly determined by second-order interactions between the stimulus aperture and the underlying orientation.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros et al.
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.
    1. Neuroscience

    Content-specific activity in frontoparietal and default-mode networks during prior-guided visual perception

    Carlos González-García et al.
    Prior experience alters content-specific neural representations of visual input in frontoparietal and default-mode networks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions

    Achim Werner et al.
    Simultaneous phosphorylation of multiple substrate motifs drives switch-like target recognition and monoubiquitylation by an E3 ligase during metazoan development.
    1. Cell Biology

    CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

    Kian-Yong Lee et al.
    The CYK-4 subunit of the broadly conserved intercellular bridge component centralspindlin, but not its ZEN-4 subunit, is essential for the cytokinesis-like closure of intercellular bridges that cellularizes oocytes to separate them from germline syncytia.

Refine your results by:

Type
Research categories