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    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu, Raymond J Dolan ... Timothy E Behrens
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Neuroscience

    Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo

    Carolin Gehr, Jeremie Sibille, Jens Kremkow
    Excitatory and inhibitory neurons in the mouse superior colliculus receive comparably strong inputs from retinal ganglion cells, in contrast to the thalamocortical system.
    1. Stem Cells and Regenerative Medicine

    Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

    Diego Balboa, Jonna Saarimäki-Vire ... Timo Otonkoski
    Mutations causing proinsulin misfolding trigger unfolded protein response and lead to impaired proliferation and reduced mTORC1 signalling of developing beta-cells in a patient-derived induced pluripotent stem cell disease model.
    1. Neuroscience

    Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

    Michael Bucher, Stephan Niebling ... Marina Mikhaylova
    Autism-associated SHANK3 missense mutations result in differential protein folding, stability, and intramolecular dynamics affecting its turnover at the synapse.
    1. Neuroscience

    Language experience shapes predictive coding of rhythmic sound sequences

    Piermatteo Morucci, Sanjeev Nara ... Nicola Molinaro
    A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
    1. Cell Biology
    2. Cancer Biology

    miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

    Taichi Isobe, Shigeo Hisamori ... Yohei Shimono
    Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.
    1. Structural Biology and Molecular Biophysics

    Structural basis for the reaction cycle of DASS dicarboxylate transporters

    David B Sauer, Noah Trebesch ... Da-Neng Wang
    Structures of multiple states of two dicarboxylate transporters explain the conformational changes needed for substrate import.
    1. Cell Biology

    Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis

    Chun-Wei Chen, Jeffery B Chavez ... Bruce J Nicholson
    A unique functional comparison of the major endometrial cell types from 44 control and endometriosis patients demonstrates not only a uterine origin of the disease, but also that endometrial to mesothelial cell gap junctions are required for invasive lesion formation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic effects on promoter usage are highly context-specific and contribute to complex traits

    Kaur Alasoo, Julia Rodrigues ... Daniel J Gaffney
    Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.
    1. Neuroscience

    The contribution of temporal coding to odor coding and odor perception in humans

    Ofer Perl, Nahum Nahum ... Rafi Haddad
    Human participants fail to discriminate between odor sequences that activate the same neurons at different orders, pointing against a substantial role for neuron activation time in the odor code.