3,736 results found
    1. Chromosomes and Gene Expression

    Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

    Wanqing Shao et al.
    Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Homing Genetic Elements: Mobile DNAs and switching mating types in yeast

    Laura N Rusche
    The gene that allows budding yeast cells to switch their mating type evolved from a newly discovered family of genes named weird HO.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Phenotypic Diversity: Setting the bar

    Charles Y Feigin, Ricardo Mallarino
    Analyzing the genomes of rock pigeons demonstrates that genetic variation comes in many forms and can have unexpected origins.
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    1. Stem Cells and Regenerative Medicine

    Cutting Edge: Promoting international collaboration and creativity in doctoral students

    Christopher M Groen et al.
    Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.
    1. Neuroscience

    Learning: The cerebellum influences vocal timing

    Court Hull
    We are starting to understand how the cerebellum contributes to vocal learning in songbirds.
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    1. Cancer Biology

    Translational Oncology: A signature for success

    Joaquín M Espinosa, Kelly D Sullivan
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  1. Research: Publication bias and the canonization of false facts

    Silas Boye Nissen et al.
    Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
    1. Neuroscience

    Endocytosis: Recycling at synapses

    Owen P Gross, Henrique von Gersdorff
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