23 results found
    1. Developmental Biology

    Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

    Stanislao Igor Travisano et al.
    Notch ligands Jag1 and Dll4 and their effector Ephb2 are required in sinus venosus endocardium for primitive coronary vasculature formation and later for arterial differentiation and maturation of coronary endothelium.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips et al.
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

    Michael RM Harrison et al.
    Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

    June H Tan et al.
    The switch from ubiquinone to rhodoquinone synthesis that is required for parasitic helminths to survive in anaerobic host tissues is due to alternative splicing of polyprenyltransferase COQ-2.
    1. Neuroscience

    Neuroscience: Multitasking on the run

    Mary E Hatten, Stephen G Lisberger
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    1. Neuroscience

    Value generalization in human avoidance learning

    Agnes Norbury et al.
    Individual differences in generalization of aversive value (but not safety information) during human active avoidance learning specifically predict experience of anxiety and intrusive thoughts.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Chromosomes and Gene Expression

    Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

    Madhusudhan Srinivasan et al.
    In G1 cells, Scc2 loads and maintains cohesin on chromosomes by counteracting a Wapl-independent releasing activity, which is neutralized in S phase by CDK1.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

    Dana Gancz et al.
    Cardiac lymphatic vessels of heterogeneous origins and molecular signatures support cardiac growth and regeneration.
    1. Neuroscience

    C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor

    Alan Tran et al.
    Caenorhabditis elegans require a GPCR to recognize and rapidly escape from toxin-producing Streptomyces at their head or tail.

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