96 results found
    1. Evolutionary Biology

    Evolutionary conflicts and adverse effects of antiviral factors

    Daniel Sauter, Frank Kirchhoff
    Innate antiviral factors do not always perfectly distinguish between self and foreign, and potential adverse effects of antiviral defense mechanisms for the host have been discussed.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina et al.
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
    1. Microbiology and Infectious Disease

    SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

    Anna Z Mykytyn et al.
    Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
    1. Microbiology and Infectious Disease

    Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

    Michaela Gregorova et al.
    Post-acute or long-COVID is associated with bystander T-cell activation and a recurring antimicrobial resistant, bacterial ventilator-associated pneumonia.
    1. Immunology and Inflammation

    Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

    Ghada Alsaleh et al.
    Declining TFEB and autophagy levels with age are key to poor vaccination efficacy in the elderly.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Viruses: Neutralizing SARS-CoV-2

    Eric Poeschla
    Experiments with hybrid viruses are illuminating how SARS-CoV-2 can escape neutralizing antibodies.
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    1. Neuroscience

    Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

    Aashutosh Vihani et al.
    Semiochemicals activate a subpopulation of sexually dimorphic olfactory sensory neurons.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

    Yiska Weisblum et al.
    SARS-CoV-2 spike variants that resist neutralization by therapeutic antibodies or convalescent plasma can be generated in the laboratory and exist at low frequency in natural populations.

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