13 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    MERS-CoV spillover at the camel-human interface

    Gytis Dudas et al.
    MERS-CoV infections in the Arabian Peninsula are the result of several hundred spillover events from viruses circulating in camels into the human population.
    1. Ecology
    2. Epidemiology and Global Health

    Effectiveness of traveller screening for emerging pathogens is shaped by epidemiology and natural history of infection

    Katelyn M Gostic et al.
    Pathogen natural history, epidemiological knowledge, human behavior and epidemic progression determine whether symptom screening and questionnaires are effective barriers to geographic spread of infection by travelers.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transmission genetics of drug-resistant hepatitis C virus

    Nicholas van Buuren et al.
    Interactions between viral genomes within the same cells can impact the selection of drug-resistant variants and this has been finessed by hepatitis C virus.
    1. Microbiology and Infectious Disease

    Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

    Matthew D Daugherty et al.
    Evolutionary innovation and turnover in the IFIT1 antiviral gene family has led to diverse repertoires of antiviral specificity across mammals.
    1. Microbiology and Infectious Disease

    Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

    Melinda Ng et al.
    NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al.
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

    Yize Li et al.
    Endogenous double-stranded RNA is generated in human cells and leads to RNase L activation and consequent cell death unless neutralized by adenosine deaminase acting on RNA1 (ADAR1).
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

    Don B Gammon et al.
    Novel virus-host systems yield insights into how Lepidopterans (moths and butterflies) combat RNA virus infection and reveal that poxvirus A51R proteins can suppress the host's immune system and stabilize microtubules in host cells.

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