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    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías et al.
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
    1. Neuroscience

    Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

    David Orduz et al.
    During the second postnatal week, a temporary circuit made up of specific types of neurons plus the precursors of oligodendrocytes is established in the brain, and may promote the maturation of oligodendrocytes in preparation for myelination.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith et al.
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring

    Martina Riva et al.
    The complete elimination of a transient superficial population of neurons, and associated immature circuits, is required for the emergence of functional properties in the mature cerebral cortex.
    1. Neuroscience

    Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

    Joachim Ahlbeck et al.
    Combined optogenetics and electrophysiology in vivo identified the cellular substrate of hippocampal drive that initiates the oscillatory entrainment of prefrontal cortex in neonatal mice.
    1. Cell Biology
    2. Developmental Biology

    Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

    Felipe Mora-Bermúdez et al.
    Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
    1. Stem Cells and Regenerative Medicine

    A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

    Jinsuke Nishino et al.
    A set of genes that are turned on only within time-limited windows—including genes encoding RNA binding molecules, let-7 microRNAs and IMP1—control developmental switches in stem cell properties between fetal development and adulthood.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun et al.
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Developmental Biology
    2. Neuroscience

    Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

    Einav Wircer et al.
    Experiments in zebrafish reveal a new role for a critical hypothalamic transcription factor, orthopedia, in controlling developmental neuropeptide balance in a discrete oxytocin-producing neuronal circuit whose disrupted development affects social behavior.
    1. Cell Biology
    2. Human Biology and Medicine

    A critical role for mTORC1 in erythropoiesis and anemia

    Zachary A Knight et al.
    Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia