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Stem Cells and Regenerative Medicine
marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response
Rongbo Li et al.
Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice
Lorriane Eley et al.
Identification of a novel source of progenitor cells that form arterial valve leaflets and that, when disrupted, can lead to bicuspid arterial valve, the most common human cardiac malformation.
Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls
An-Sofie Desmet et al.
In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
axis controls the cytoskeleton and confers cellular properties required for alveologenesis
Kuan Zhang et al.
Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a
axis is a major determinant of alveolar formation.
Revisiting the role of Dcc in visual system development with a novel eye clearing method
Robin J Vigouroux et al.
A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
Human Biology and Medicine
miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway
Taichi Isobe et al.
Insights into the roles and mechanisms of two of the miRNAs upregulated in human breast cancer stem cells in at least some breast cancers are presented.
A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit,
Yi Bessie Liu et al.
A mouse with a defined mutation in an extracellular matrix protein that is expressed in selected neurons sheds light on circuit abnormalities producing transient hyperkinetic movements.
Structural Biology and Molecular Biophysics
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling
Nicolas Aznar et al.
Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.
Chromosomes and Gene Expression
Human Biology and Medicine
is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy
Stefan Heinrichs et al.
Reduced expression of
contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.
Shank3 modulates sleep and expression of circadian transcription factors
Ashley M Ingiosi et al.
Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.
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