3,576 results found
    1. Developmental Biology
    2. Neuroscience

    A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

    Alokananda Ray, Xin Li
    Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
    1. Cell Biology

    Self-assembly of pericentriolar material in interphase cells lacking centrioles

    Fangrui Chen, Jingchao Wu ... Anna Akhmanova
    In the absence of centrioles, components of pericentriolar material can self-organize into a single compact microtubule-organizing center through dynein-mediated transport of pericentrin-containing protein complexes if CAMSAP- and Golgi-mediated pathways of microtubule minus-end stabilization and anchoring are disabled.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta, Matthias Merkel ... Jeffrey D Amack
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.
    1. Computational and Systems Biology
    2. Neuroscience

    Endotaxis: A neuromorphic algorithm for mapping, goal-learning, navigation, and patrolling

    Tony Zhang, Matthew Rosenberg ... Markus Meister
    A neural circuit model reveals how biological brains may implement rapid learning and navigation in complex spaces.
    1. Cell Biology
    2. Developmental Biology

    Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

    Naonobu Fujita, Wilson Huang ... Amy A Kiger
    Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Neuroscience

    Landmark-based spatial navigation across the human lifespan

    Marcia Bécu, Denis Sheynikhovich ... Angelo Arleo
    Landmark cues preclude complex and flexible spatial navigation in human development and aging.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner, Abdul Naseer Malmi-Kakkada ... John B Wallingford
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Neuroscience

    NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

    Brandon W Hughes, Benjamin M Siemsen ... Makoto Taniguchi
    Social defeat stress induces transcription factor Npas4 expression in the medial prefrontal cortex and its chronic stress-induced changes in excitatory synaptic transmission, reduction of dendritic spine density, and anhedonia-like behaviors.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang, Jean-François Rupprecht, Timothy E Saunders
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.

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